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Plausible degradation pathways include: Serum aminopeptidases (cleaving from the N-terminus) Endopeptidases (internal bond cleavage) Hepatic uptake and degradation Renal clearance (though direct renal excretion of intact peptide of this size is typically limited) Whether BPC-157 generates active metabolites i.e., smaller peptide fragments that retain biological activity is not established in the public literature

doi: 10.3389/fcell.2024.1435125 Received 19 May 2024 Accepted 27 June 2024 Published 11 July 2024 Volume 12 - 2024 Edited by Takehito Ouchi, Tokyo Dental College, Japan Reviewed by Kui Xu, Anhui University of Chinese Medicine, China Xiaolei Li, University of Pennsylvania, United States Updates Copyright 2024 Zheng, Liu, Sun and Meng

80,81 However, subnormal ALP levels are not specific to this condition and can also be seen in other liver diseases

Concurrently, the aberrant expression of iron metabolism-related genes, along with intracellular iron accumulationwhich is positively correlated with inflammatory responsescollectively promotes ferroptosis and subsequent tissue injury (27)